Alzheimer’s disease may be associated with insulin resistance, constituting a third type of diabetes, according to two new studies. This Model is based on several observations including an increased risk of developing Alzheimer’s disease for diabetic patients, and reduced insulin levels in the brain tissue of Alzheimer’s disease patients.Though intriguing, the existing evidence does not reveal if defective insulin signalling is causative of Alzheimer’s or how insulin resistance impacts cognitive function. Two back-to-back research articles led by Konrad Talbot, Steve Arnold and colleagues at the University of Pennsylvania and by Fernanda De Felice, Sergio Ferreria and colleagues at the University of Rio de Janeiro, address the connection between insulin resistance and Alzheimer’s disease. Full Text
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